Mitragynine is the principal alkaloid of kratom (Mitragyna speciosa), a Southeast Asian tree. It is a partial mu-opioid receptor agonist; at low doses it has stimulant effects, at higher doses opioid-like effects. Controversial regulatory status in the US. Not stocked by Kodiac. This monograph is provided for research and educational reference.
Intrigue 0–100 blends mechanism novelty, evidence strength, and translational potential. Kodiac editorial, not peer-reviewed.
Indole alkaloid / partial mu-opioid agonist
The principal alkaloid of Mitragyna speciosa (kratom), a partial mu-opioid agonist with low respiratory depression liability and significant abuse and dependence potential.
Abstract
Mitragynine (CAS 4098-40-2; molecular formula C23H30N2O4; molecular weight 398.49) is the principal indole alkaloid of Mitragyna speciosa (kratom), a tree native to Southeast Asia. The compound and its 7-hydroxymetabolite are partial mu-opioid receptor agonists with G-protein-biased signaling that produces analgesia with reduced respiratory depression compared with classical opioids at equivalent analgesic potency. Kratom and mitragynine have substantial dependence and addiction liability with chronic use; FDA has issued multiple warnings, and DEA has attempted scheduling (currently not federally scheduled but prohibited in some states). The compound is sold as kratom leaf, kratom extracts, and isolated mitragynine. Doses are highly variable; typical kratom leaf doses are 1 to 5 grams.
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