Lion’s mane mushroom (Hericium erinaceus) contains hericenones and erinacines that promote nerve growth factor (NGF) production. Used as a nootropic and being studied for cognitive decline. Not stocked by Kodiac. This monograph is provided for research and educational reference.
Intrigue 0–100 blends mechanism novelty, evidence strength, and translational potential. Kodiac editorial, not peer-reviewed.
Medicinal mushroom / NGF inducer
A medicinal mushroom containing hericenones and erinacines with documented NGF induction and modest cognitive enhancement in mild cognitive impairment.
Abstract
Hericium erinaceus (Lion’s Mane mushroom) is a medicinal mushroom containing hericenones (in the fruiting body) and erinacines (in the mycelium), both classes of which induce nerve growth factor (NGF) expression in vitro and in vivo. NGF is critical for cholinergic neuron survival and function. A small randomized trial in Japanese subjects with mild cognitive impairment showed cognitive endpoint improvements with chronic Lion’s Mane supplementation (3 grams per day for 16 weeks). Additional studies suggest peripheral nerve regeneration applications and modest anxiolytic effects. The compound is sold as both fruiting body extracts and mycelium-on-grain products; the latter contains erinacines but also significant residual grain (rice, oats) which has led to controversy about active constituent content. Doses are typically 500 mg to 3 grams per day of the fruiting body extract.
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The full reference document covers compound identification, discovery and developmental history, mechanism of action, pharmacokinetics, sourcing and quality verification, and a curated reference list. Embedded inline below; download for offline reading.
FOR RESEARCH USE ONLY. Not for medical, diagnostic, or therapeutic purposes. Not for human consumption. All information is provided for research and educational purposes only.