L-methylfolate (5-MTHF) is the active form of folate, bypassing the MTHFR enzyme that some patients have polymorphisms in. Used for depression augmentation (especially in MTHFR variants) and for pregnancy. Not stocked by Kodiac. This monograph is provided for research and educational reference.
Intrigue 0–100 blends mechanism novelty, evidence strength, and translational potential. Kodiac editorial, not peer-reviewed.
Active folate / 5-methyltetrahydrofolate
The active form of folate (5-methyltetrahydrofolate) used clinically for major depression adjunct and for individuals with MTHFR polymorphisms.
Abstract
L-Methylfolate (5-methyltetrahydrofolate, 5-MTHF; CAS 31690-09-2) is the active form of folate (vitamin B9), bypassing the methylenetetrahydrofolate reductase (MTHFR) step that is impaired in individuals with C677T or A1298C MTHFR polymorphisms. The compound is FDA-approved as Deplin (medical food) for major depressive disorder, particularly in patients with low folate status or MTHFR polymorphisms. Mechanism is provision of methyl groups for SAM-e synthesis and downstream methylation, including monoamine neurotransmitter synthesis. Doses are typically 1 to 15 mg per day; clinical use for depression is at the high end (7.5 to 15 mg).
Read the full monograph
The full reference document covers compound identification, discovery and developmental history, mechanism of action, pharmacokinetics, sourcing and quality verification, and a curated reference list. Embedded inline below; download for offline reading.
FOR RESEARCH USE ONLY. Not for medical, diagnostic, or therapeutic purposes. Not for human consumption. All information is provided for research and educational purposes only.